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ea0041oc6.4 | Diabetes therapy & complications | ECE2016

LEA29Y expression in transgenic porcine islets prevents islet graft rejection in humanized mice without systemic immunosuppressive therapy

Wolf-van Buerck Lelia , Schuster Marion , Baehr Andrea , Klymiuk Nik , Wolf Eckhard , Seissler Jochen

Transplantation of pancreas or isolated Langerhans islets can cure type 1 diabetes. Xenografts from transgenic pigs represent a promising source to overcome the shortage of organ donors. We investigated the immunosuppressive effect of local LEA29Y expression (a high-affinity variant of CTLA4-Ig) by transplantation of neonatal porcine islet-like clusters (NPICCs) from INSLEA29Y transgenic pigs into humanized mice. NPICCs from 1–5 day-old pigs expressing LEA29Y und...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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